Can You Have Cervical Cancer Again After Hysterectomy
Treatment of Recurrent Cervical Cancer
Treatment for recurrent cervical cancer may include surgery, radiation, chemotherapy, precision cancer medicines or participation in a clinical trial.
Medically reviewed by Dr. C.H. Weaver K.D. eight/2021
When cervical cancer has been detected or has returned following initial treatment with surgery, radiation therapy and/or chemotherapy, it is said to be recurrent or relapsed. The course of handling for relapsed cervical cancer depends on what handling a patient has previously received and where the recurrence is located. Some patients who accept recurrence of cervical cancer within the pelvis can exist treated with boosted surgery or with radiation therapy, if no radiation therapy was given previously. Recurrence of cervical cancer outside the pelvis is difficult to treat.
The following is an overview of the handling of recurrent cervical cancer. The information is intended to assist brainwash y'all nigh treatment options and to facilitate a shared controlling process with your treating physician.
Treatment depends on many factors, including what treatment the patient had before, the location of the recurrence and the overall condition of the patient. If the patient had surgery to remove the cervix and the cancer comes back merely in a small area near the performance, radiations therapy may be administered. If the patient already received radiation therapy to the pelvis, radiation therapy cannot exist administered again to the aforementioned part of the body. Some patients with recurrent cervical cancer in the pelvis tin can undergo an extensive surgical process that removes the cancer and many pelvic organs. Other patients take recurrent cervical cancer exterior the pelvis and may receive chemotherapy or radiations therapy to alleviate symptoms.
Recurrent Cervical Cancer Later on Surgery
A radical hysterectomy is a very constructive therapy if the cancer has not spread beyond the cervix. At times, a small surface area of cancer has spread beyond the neck and cancer cells may be present at the edge of the surgical specimen. Usually, this can exist adamant but after the surgery when the specimen is examined under the microscope. Other times, the region of the operation may be contaminated with microscopic cancer cells. The presence of microscopic areas of cancer cells can cause the cancer to return some time after the surgery. This state of affairs occurs more ofttimes in patients with large phase IB or stage 2 cervical cancer.
Patients with a modest amount of cancer recurrence in the area of previous surgery can exist treated in an try to rid the cancer again. If the patient has not received radiation therapy to the pelvis, external beam radiation therapy to the area of the recurrence tin impale cancer cells after the surgery. Patients who have received prior radiation therapy may exist able to undergo a pelvic exenteration, which is an extensive surgical procedure that removes the cancer and many pelvic organs. A pelvic exenteration is only performed if cancer cannot be detected elsewhere in the body and all of the cancer tin can be removed by the surgery. Approximately ane-third of patients with recurrent cancer will survive gratuitous of cancer later on handling with radiation therapy or pelvic exenteration.
Other patients already have small amounts of cancer that take spread exterior the pelvis and were not removed by surgery. These cancer cells cannot exist detected with any of the currently available tests. Undetectable areas of cancer exterior the pelvis are referred to as micrometastases. The presence of microscopic areas of cancer cells can cause the cancer to return outside the pelvis some time later on the surgery. Please see the section below for more than information.
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Recurrent Cervical Cancer After Radiation Therapy
Depending on the features of the cervical cancer, some patients will experience a recurrence of the cervical cancer after radiations therapy. In these patients, cancer cells may accept survived despite the radiation therapy. Other patients already take small amounts of cancer that have spread exterior the pelvis and were non treated by the radiation. These cancer cells cannot be detected with whatever of the currently bachelor tests. Undetectable areas of cancer outside the pelvis are referred to as micrometastases. The presence of these microscopic areas of cancer or surviving cancer cells tin crusade the relapses that follow treatment with radiations therapy.
Once a patient has received radiation therapy to the pelvis, more radiation therapy cannot safely be administered to the same area. Patients who have received prior radiation therapy may exist able to undergo a pelvic exenteration, which is an all-encompassing surgical procedure that removes the cancer and many pelvic organs. A pelvic exenteration is only performed if cancer cannot be detected elsewhere in the body and all of the cancer can exist removed by the surgery. Approximately ane-third of patients with recurrent cancer will survive free of cancer afterwards handling with radiation therapy or pelvic exenteration.
Recurrent Cervical Cancer Exterior the Pelvis
Cervical cancer that has spread to distant organs and bones is difficult to care for. Historically, patients with metastatic cervical cancer have been considered incurable. Some patients are offered treatment with chemotherapy for the purpose of prolonging their duration of survival and alleviating symptoms from progressive cancer. Other patients are managed with efforts to reduce pain or bleeding, including local radiation therapy to affected parts of the trunk.2,3
There is no good unmarried chemotherapy arroyo that tin can improve the length of survival in patients with metastatic cervical cancer. Treatment with Platinol® tin produce shrinkage in fifteen-25% of patients with metastatic cervical cancer. Many clinical trials take combined Platinol® with other chemotherapy drugs in hopes of improving cancer shrinkage and survival. Although these combination regimens can take more side furnishings, length of survival has not been improved over Platinol® alone. Unfortunately, these chemotherapies typically work for only a few months before the cervical cancer begins to abound once more.
- Systemic Treatment for Metastatic Cervical Cancer
References
- nccn.org/professionals/physician_gls/f_guidelines.asp#site
- Takeuchi S, Shoji T, Kagabu M, et al. Phase 2 studies of multiple peptides cocktail vaccine for treatment-resistant cervical and ovarian cancer. Journal of Clinical Oncology. 2015; 33 (suppl; abstract 5567).
- Stevanovic S, Draper L, Langhan M, et al. Complete regression of metastatic cervical cancer after treatment with homo papillomavirus-targeted tumor-infiltrating T cells. Journal of Clinical Oncology, 2015; x:33(four): 1543-1550. Doi: ten.1200/JCO.2014.58.9093.
Source: https://news.cancerconnect.com/cervical-cancer/treatment-of-recurrent-cervical-cancer
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